Cell interactions in asthmatic inflammation

哮喘炎症中的细胞相互作用

• 批准号: nhmrc : 153778
• 负责人: Dr J. Margaret Hughes
• 金额: $ 29.18万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-interactions-asthmatic-inflammation/76884
• 关键词: Cell; interactions; asthmatic; inflammation

Asthma is a significant burden to the health care system and to individual sufferers. Currently we can treat asthma with corticosteroids to reduce inflammation in the lung but the side effects of these medications, particularly in children, make them less than ideal treatments. In order to design a more specific treatment for asthma, which would only target the inflammatory cells which are involved in the lung, we need to understand how these cells behave and what initiates the cascade of events in the lung. This project is designed to investigate how chemical mediators, cytokines, are produced by various cells in the lung and how they induce lung cells to make structural changes to the lung tissue and increase the inflammation. The source and specific types of cytokines released are being investigated to provide important information regarding the disease process of asthma. From this new knowledge, design of specific new treatments, with fewer unwanted side-effects, should be possible.

哮喘是卫生保健系统和个体患者的重大负担。目前，我们可以用皮质类固醇治疗哮喘，以减少肺部炎症，但这些药物的副作用，特别是对儿童的副作用，使它们不是理想的治疗方法。为了设计一种更具体的治疗哮喘的方法，只针对与肺部有关的炎症细胞，我们需要了解这些细胞的行为以及是什么引发了肺部的一系列事件。该项目旨在研究肺部各种细胞如何产生化学介质，细胞因子，以及它们如何诱导肺细胞对肺组织进行结构改变并增加炎症。正在研究释放的细胞因子的来源和特定类型，以提供有关哮喘疾病过程的重要信息。根据这一新知识，设计出具有更少副作用的特定新疗法应该是可能的。