Accessing the therapeutic potential of carbon monoxide

发挥一氧化碳的治疗潜力

• 批准号: FT130100033
• 负责人: Prof Massimiliano Massi
• 金额: $ 49.2万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100033
• 关键词: Accessing; therapeutic; potential; carbon; monoxide

Despite carbon monoxide being regarded as the ”silent killer”, it is now established that this molecule has beneficial effects for a number of conditions and pathologies, including inflammation, organ transplant rejection, bacterial infection, acute liver failure and as an aid in cancer therapies. This project proposes to explore the photochemistry of rhenium-containing species to discover more efficient carbon monoxide delivery agents. By combining synthetic chemistry, photochemistry and cellular biology it is anticipated that this multidisciplinary research programme will advance the area of carbon monoxide therapies by preparing safer agents for the targeted and controlled delivery of carbon monoxide.

尽管一氧化碳被认为是“沉默的杀手”，但现在已经确定这种分子对许多疾病和病理都有有益的影响，包括炎症、器官移植排斥、细菌感染、急性肝衰竭，并有助于癌症治疗。本项目拟探索含铼物质的光化学性质，以发现更有效的一氧化碳递送剂。通过结合合成化学、光化学和细胞生物学，预计这一多学科研究计划将通过制备更安全的一氧化碳靶向和控制递送剂来推进一氧化碳治疗领域。