Centre for Clinical Research Excellence in Anxiety and Neuroscience

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This Centre will bring together Australia's leading anxiety and neuroscience researchers to develop, evaluate, and disseminate better treatments of anxiety. Epidemiological studies indicate that anxiety disorders are common, with lifetime prevalence estimated to be as high as 15% (1). These disorders share the features of excessive physiological arousal in response to feared stimuli, and this leads to pervasive avoidance that has a debilitating impact on people's lives. In addition, anxiety is often present as a co-morbid feature of other major disorders, such as schizophrenia, substance use, and depression. Anxiety is one of the world's major health burdens; it costs $44 billion per year in the United States. Health agencies around the world are now putting unprecedented resources into understanding the neural bases of anxiety and its reduction. Building on recent advances in the neuroscience of anxiety, the Centre will expand the capacity for neurotransmitter modulation during therapy to reduce anxiety disorders. By extensive training programs with community clinicians, the Centre will conduct large-scale community trials to assess effectiveness of new approaches. The Centre will foster a new generation of neuroscience researchers and clinicians who are skilled in translating basic science findings into clinical practice.