Changes to design aspects of ongoing randomised controlled trials (RCT)

随机试验提供了治疗效果的最佳证据，因为对每个患者组进行了无偏倚的治疗分配，但对这些试验的事后分析仍然可能导致治疗效果估计的严重偏倚。这种情况发生的程度并没有得到读者的充分认识。本研究将检查调整预先指定的分析的策略，这些分析没有偏见，并以清单的形式提供一个明确的框架，以指导未来的试验分析。

Randomised trials provide best evidence of treatment effects due to unbiased allocation of treatments to each patient group but post hoc analysis of these trials can still lead to substantial bias of estimates of treatment effect. The extent to which this occurs is not fully appreciated by the reader. This research will examine strategies for adjusting pre-specified analyses which are free from bias and provide a clear framework, in the form of a checklist to guide future trial analyses.