Changes in protein glycosylation promote endometrial receptivity leading to successful implantation

蛋白质糖基化的变化促进子宫内膜容受性，从而成功着床

• 批准号: nhmrc : 1047056
• 负责人: Dr Tracey Edgell
• 金额: $ 32.62万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/changes-protein-glycosylation-successful-implantation/111902
• 关键词: Changes; protein; glycosylation; promote; endometrial

~15% of couples are unable to have children. Their reliance on reproductive technologies (eg, IVF) has increased 4 fold over the past decade. One reason for infertility is that the lining of the uterus (endometrium) is not able to allow an embryo to attach – a key event in establishing healthy pregnancy. There is no test to assess whether the endometrium is ‘receptive’ to an embryo. We will develop special assays for a test and provide a basis for treatment without recourse to IVF.

约15%的夫妇无法生育。他们对生殖技术（如IVF）的依赖在过去十年中增加了4倍。不孕症的一个原因是子宫内膜（子宫内膜）不能允许胚胎附着-这是建立健康妊娠的关键事件。没有测试来评估子宫内膜是否“接受”胚胎。我们将开发特殊的检测方法，并为不求助于IVF的治疗提供基础。