Characterisation of Anti-HBs Responses in Patients Undergoing Functional Hepatitis B Cure: Implication for Future Therapies

接受功能性乙型肝炎治愈的患者抗 HBs 反应的特征：对未来治疗的启示

• 批准号: nhmrc : 1127538
• 负责人: Dr Renae Walsh
• 金额: $ 49.43万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-anti-hbs-future-therapies/948031
• 关键词: Characterisation; Anti; HBs; Responses; Patients

The hepatitis B virus causes liver cirrhosis and liver cancer. There is no cure for hepatitis B. However, a small number of patients can naturally rid themselves of the virus. We have identified 14 of these individuals and discovered that they have a unique immune response that is responsible for these “natural” cures. We plan to characterise this immune response and turn it into a therapeutic vaccine which can be used to cure patients who are still chronically infected.

B型肝炎病毒会导致肝硬化和肝癌。B型肝炎是无法治愈的。然而，少数患者可以自然地摆脱病毒。我们已经确定了其中的14个人，并发现他们有一种独特的免疫反应，这种免疫反应是这些“自然”治疗的原因。我们计划将这种免疫反应转化为治疗性疫苗，可用于治愈仍处于慢性感染状态的患者。