Characterisation of the RBP-RNA interactome: A transcriptome-wide approach to measuring the perturbation of post-transcriptional processes

RBP-RNA 相互作用组的表征：测量转录后过程扰动的全转录组方法

• 批准号: nhmrc : GNT1168980
• 金额: $ 4.69万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-rbp-rna-transcriptional-processes/1379484
• 关键词: Characterisation; RBP; RNA; interactome; transcriptome

Our health reflects whether our cells and can perform their daily duties without being disrupted by disorder. One family of proteins, RNA-binding proteins (RBPs), are critical to maintaining order. They do this by managing RNA molecules; the exclusive products of our genes. This study will develop the tools necessary to identify proteins engaged in RNA-binding and, in so doing, add to the catalogue of known RBPs whose dysregulation can affect human health.

我们的健康状况反映了我们的细胞是否能够在不受紊乱干扰的情况下履行其日常职责。RNA结合蛋白（RBP）是一个蛋白质家族，对维持秩序至关重要。它们通过管理RNA分子来做到这一点; RNA分子是我们基因的专属产物。这项研究将开发必要的工具来识别参与RNA结合的蛋白质，并在这样做的过程中，添加到已知的RBP的目录中，这些RBP的失调会影响人类健康。