Characterisation of the RBP-RNA interactome: A transcriptome-wide approach to measuring the perturbation of post-transcriptional processes

我们的健康状况反映了我们的细胞是否能够在不受紊乱干扰的情况下履行日常职责。一种蛋白质家族，RNA结合蛋白(RBPs)，对维持秩序至关重要。它们通过管理RNA分子来做到这一点；RNA分子是我们基因的专有产物。这项研究将开发必要的工具来识别参与RNA结合的蛋白质，并在这样做的同时，增加已知限制性商业惯例的目录，这些限制性商业惯例的失调可能影响人类健康。

Our health reflects whether our cells and can perform their daily duties without being disrupted by disorder. One family of proteins, RNA-binding proteins (RBPs), are critical to maintaining order. They do this by managing RNA molecules; the exclusive products of our genes. This study will develop the tools necessary to identify proteins engaged in RNA-binding and, in so doing, add to the catalogue of known RBPs whose dysregulation can affect human health.