Characterising the function of niche-derived Neuregulin 1 in colorectal cancer

结直肠癌每年影响成千上万的澳大利亚人。一种特殊的细胞群，被称为癌症干细胞，不断产生新的肿瘤细胞。确定控制这些独特细胞行为的机制对于开发新药至关重要。我们已经确定神经调节蛋白1是增强癌症干细胞作用的关键因子。我们的目标是研究结直肠癌是如何介导的，以及靶向神经调节蛋白-1是否是一种有希望的治疗选择。

Colorectal cancer affects thousands of Australians each year. A specialised cell population, named cancer stem cells, continuously produces new tumour cells. Defining mechanisms controlling the behaviour of these unique cells is critical to develop new drugs. We have identified that Neuregulin-1 is a key factor that enhances the action of cancer stem cells. We aim to study how colorectal cancer is mediated and whether targeting Neuregulin-1 is a promising therapeutic option.