Characterising the mechanism between periodontal disease and the onset of cardiovascular disease

表征牙周病与心血管疾病发病之间的机制

• 批准号: nhmrc : GNT1160925
• 负责人: Dr Danielle Kamato
• 金额: $ 32.72万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterising-mechanism-periodontal-cardiovascular-disease/1349329
• 关键词: Characterising; mechanism; between; periodontal; disease

Atherosclerosis commences by the trapping of cholesterol to sugar coated proteins known as proteoglycans which leads to the formation of plaque. As yet, there is no pharmaceutical treatment that directly targets the disease process in the artery wall. Elucidation of the mechanisms responsible for the initiation of lipid deposition in the artery wall will enable identification of suitable therapeutics targets. Such an agent would be used with a statin to prevent atherosclerosis.

动脉粥样硬化始于胆固醇被糖衣蛋白多糖捕获，从而导致斑块的形成。到目前为止，还没有直接针对动脉壁疾病过程的药物治疗。阐明导致动脉壁脂肪沉积的机制将有助于确定合适的治疗靶点。这种药物将与他汀类药物一起使用，以防止动脉粥样硬化。