Characterising the Muscarinic Receptor Deficit in Schizophrenia

对精神分裂症患者的大脑进行尸检发现，M受体大量丢失。如果在活着的患者中也能证实这一点，这很可能在临床上非常重要。在开发出一种新的扫描技术，显示活着的大脑中的毒碱受体后，我们现在将扫描精神分裂症患者，看看他们是否也表现出这种受体丢失，并看看它对他们的影响。这可能会为理解和治疗这种疾病打开新的大门。

Post-mortem examination of the brains of schizophrenia patients reveals a substantial loss of muscarinic receptors. This is likely to be clinically very important if it can also be confirmed in living patients. Having developed a new scanning technique that shows muscarinic receptors in the living brain, we will now scan patients with schizophrenia to see if they also show this receptor loss, and see how it affects them. This could open new doors to understanding and treating the disease.