Chemokines in osteoclast differentiation

破骨细胞分化中的趋化因子

• 批准号: nhmrc : 481946
• 负责人: A/Pr Nigel Morrison
• 金额: $ 28.29万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chemokines-osteoclast-differentiation/96189
• 关键词: Chemokines; osteoclast; differentiation

Chemokines are small molecules that are released by a number of cell types, particularly monocytes, when inflammation occurs. Chronic inflammatory disease is associated with severe bone erosion and loss of bone quality. Surprisingly, chemokines control osteoclast development as well as macrophage activation; even if the osteoclast has formed, blocking chemokine signalling prevents bone resorption. Chemokines are a new and exciting target to control osteoclast formation.

趋化因子是当炎症发生时由许多细胞类型，特别是单核细胞释放的小分子。慢性炎症性疾病与严重的骨质侵蚀和骨质丧失有关。令人惊讶的是，趋化因子控制破骨细胞的发育以及巨噬细胞的活化;即使破骨细胞已经形成，阻断趋化因子信号传导也会防止骨吸收。趋化因子是控制破骨细胞形成的新靶点。