Tissue protein metabolism in catabolic states

我的NSERC资助的研究项目涉及蛋白质和氨基酸的新陈代谢，以及蛋白质和氨基酸营养。氨基酸是一组复杂的营养物质，其中许多(必需的氨基酸)不能在体内形成。这些氨基酸必须从饮食来源提供，尽管当饮食供应有限时，体内的蛋白质储备是一种有限的长期资源。我实验室正在进行的研究涉及人体如何使用氨基酸，它们如何储存和在需要的时候再次释放，以及在影响许多动物和人类的不同压力状态下，什么形式的氨基酸营养是最佳的。将研究两种应激状态，即对氨基酸的高需求，哺乳和炎症。

My NSERC-supported research program concerns the metabolism of protein and amino acids, and protein and amino acid nutrition. Amino acids are a complex set of nutrients, of which many (the essential amino acids) cannot be formed in the body. These amino acids must be provided from a dietary source, although protein reserves within the body act as a limited term resource when dietary supplies are limiting.Ongoing research in my laboratory concerns how amino acids are used by the body, how they are stored and released again in times of need, and what forms of amino acid nutrition are optimal during different stress states, that affect many species of animals and humans. Two stress states typified by high demand for amino acids, lactation and inflammation, will be studied.