Regulation of the anti-tumour immune response by the chemokine decoy receptor CCX-CKR

趋化因子诱饵受体 CCX-CKR 调节抗肿瘤免疫反应

• 批准号: nhmrc : 1030247
• 负责人: Dr Iain Comerford
• 金额: $ 37.52万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-anti-tumour-ccx-ckr/110744
• 关键词: Regulation; anti; tumour; immune; response

Melanoma is a significant cause of cancer-related deaths in Australians. Death is usually due to metastasis of the cancer to the lungs and other organs. In this project, we will take advantage of unique mouse models to determine whether inhibition of the function of a novel protein can prevent melanoma growth and metastasis to different organs. The results of this study may lead to new therapeutic approaches to control malignant melanoma and other metastatic cancers.

黑色素瘤是澳大利亚人癌症相关死亡的重要原因。死亡通常是由于癌症转移到肺部和其他器官。在这个项目中，我们将利用独特的小鼠模型来确定抑制一种新蛋白的功能是否可以阻止黑色素瘤生长和转移到不同的器官。这项研究的结果可能会导致新的治疗方法来控制恶性黑色素瘤和其他转移性癌症。