The regulation of apolipoprotein E secretion by human macrophages

人巨噬细胞对载脂蛋白E分泌的调节

• 批准号: nhmrc : 455251
• 负责人: John Scott
• 金额: $ 34.41万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-apolipoprotein-e-human-macrophages/76947
• 关键词: regulation; apolipoprotein; secretion; human; macrophages

One of the major inflammatory cells in the body, the macrophage, is involved in a number of diseases, including coronary disease. ApoE is made and released by macrophages and appears to protect against the inflammation of coronary disease and may affect other conditions, including Alzheimer's disease. We have discovered pathways regulating the production and release of apoE by macrophages, and in this project will study these pathways in great detail. By controlling the production of this important molecule we may reduce our risk of heart disease, and may be able to treat a range of inflammatory conditions which currently untreatable.

巨噬细胞是体内主要的炎症细胞之一，与包括冠心病在内的许多疾病有关。ApoE由巨噬细胞制造和释放，似乎可以防止冠状动脉疾病的炎症，并可能影响其他疾病，包括阿尔茨海默病。我们已经发现了调节巨噬细胞apoE产生和释放的途径，在本项目中将详细研究这些途径。通过控制这种重要分子的产生，我们可以降低患心脏病的风险，并可能能够治疗一系列目前无法治疗的炎症。