Regulation of the beta-secretase (BACE1) by glycosaminoglycans

糖胺聚糖对 β 分泌酶 (BACE1) 的调节

• 批准号: nhmrc : 490031
• 负责人: Prof Adrian West
• 金额: $ 37.42万
• 依托单位: Menzies Institute for Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-beta-secretase-bace1-glycosaminoglycans/81533
• 关键词: Regulation; beta; secretase; BACE1; glycosaminoglycans

Alzheimer's disease is the leading cause of dementia in the elderly. Because of the prolonged institutionalisation of patients, it is a major health care burden. This project aims to develop novel drugs which can treat Alzheimer's disease by inhibiting production of the protein which causes the neurodegeneration.

阿尔茨海默病是老年人痴呆症的主要原因。由于病人长期住院，这是一个主要的卫生保健负担。该项目旨在开发新型药物，通过抑制导致神经变性的蛋白质的产生来治疗阿尔茨海默病。