Regulation of caspase-1 activation and inflammation by PYD and CARD proteins

类风湿性关节炎等炎症性疾病是澳大利亚医疗支出的最大贡献者之一，随着人口老龄化，这些疾病的影响将在未来15-20年内急剧增加。这项研究将揭示caspase-1激活和IL-1b分泌的调节的新见解，这是慢性和急性炎症的主要原因，并将促进未来炎症性疾病治疗的发展。

Inflammatory diseases such as rheumatoid arthritis are among the largest contributors to health expenditure in Australia, and the impact of these diseases will increase dramatically over the next 15-20 years as the population ages. This research will reveal new insights into the regulation of caspase-1 activation and secretion of interleukin-1b, the primary cause of chronic and acute inflammation, and will enhance future approaches for development of treatments for inflammatory disease.