REGULATION OF LIPID METABOLISM IN SKELETAL MUSCLE BY IDOL – a novel degrader of the very low density lipoprotein receptor

IDOL 调节骨骼肌中的脂质代谢 — 一种新型极低密度脂蛋白受体降解剂

• 批准号: nhmrc : 1080036
• 负责人: Dr Anna Calkin
• 金额: $ 37.15万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-lipid-metabolism-lipoprotein-receptor/518719
• 关键词: REGULATION; LIPID; METABOLISM; SKELETAL; MUSCLE

More than 1 in 5 Australians are estimated to have increased levels of fats (triglycerides; TGs) in the blood, commonly due to excess dietary intake or genetics. The excess TGs are deposited in skeletal muscle where they can cause insulin resistance, increasing the risk of developing diabetes, the fastest growing chronic condition in Australia. I will examine whether a recently identified protein, IDOL, can reduce accumulation of TGs in skeletal muscle and protect against insulin resistance.

据估计，超过五分之一的澳大利亚人血液中脂肪（甘油三酯；TG）水平升高，通常是由于饮食摄入过多或遗传所致。多余的甘油三酯沉积在骨骼肌中，会导致胰岛素抵抗，从而增加患糖尿病的风险，而糖尿病是澳大利亚增长最快的慢性疾病。我将研究最近发现的一种蛋白质 IDOL 是否可以减少骨骼肌中 TG 的积累并防止胰岛素抵抗。