Regulation of the Nedd4 family of ubiquitin ligases by adaptor and accessory proteins in normal physiology and in disease

在某种程度上，这项提议是为了了解身体如何通过铁转运蛋白DMT1和Nramp1控制铁的摄取。我们将研究Ndfip1， Ndfip2和阻滞蛋白对这些转运蛋白的调控。我们还将研究这些蛋白质在控制泛素化中的功能，泛素化是细胞稳态所需的基本过程。这项研究的结果可能最终有助于开发针对某些人类疾病的新疗法。

In part this proposal is to understand how the body controls iron uptake through iron transporters DMT1 and Nramp1. We will study the regulation of these transporters by proteins called Ndfip1, Ndfip2 and arrestins. We will also study the functions of these proteins in controlling ubiquitination, a fundamental process required for cellular homeostasis. The results from this study may ultimately contribute to the development of novel therapies for certain human diseases.