Regulatory networks defining stem cell populations in the adult male germline

定义成年男性种系干细胞群的监管网络

• 批准号: nhmrc : GNT1164019
• 金额: $ 95.02万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulatory-networks-defining-male-germline/1379333
• 关键词: Regulatory; networks; defining; stem; cell

Stem cells are essential for maintenance and repair of many adult tissues including testis. Within a given tissue, different populations of stem cells can play contrasting roles in tissue maintenance and regeneration. We have identified a group of stem cells within the testis marked by a unique set of genes critical during embryo development. Our studies will assess the role of this new cell population in male fertility and testis repair and define genes required for its function.

干细胞对于包括睾丸在内的许多成人组织的维持和修复是必不可少的。在给定的组织内，不同的干细胞群体可以在组织维护和再生中发挥截然不同的作用。我们已经在睾丸内鉴定出一组干细胞，这些干细胞由一组在胚胎发育过程中至关重要的独特基因标记。我们的研究将评估这种新细胞群在男性生育力和睾丸修复中的作用，并确定其功能所需的基因。