Reprogramming macrophage function in the elderly to rescue impaired inflammatory responses to muscle injury

重新编程老年人的巨噬细胞功能以挽救肌肉损伤引起的炎症反应受损

• 批准号: nhmrc : GNT1100803
• 负责人: Dr Connie Jackaman
• 金额: $ 41.1万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reprogramming-macrophage-function-muscle-injury/1346136
• 关键词: Reprogramming; macrophage; function; elderly; rescue

Muscle injury in the elderly often takes longer to heal than in younger people, however the cells responsible for this delayed healing are not well understood. Key inflammatory cells required for muscle repair in young hosts are macrophages. However, during aging we have shown that macrophage function is altered, but the mechanism is unknown. This project aims to determine the mechanisms behind age-related changes to macrophages and whether they can be targeted to improve elderly muscle repair.

与年轻人相比，老年人的肌肉损伤往往需要更长的时间才能愈合，然而，导致这种延迟愈合的细胞尚未得到很好的理解。年轻宿主肌肉修复所需的关键炎症细胞是巨噬细胞。然而，在衰老过程中，我们发现巨噬细胞的功能发生了改变，但其机制尚不清楚。该项目旨在确定巨噬细胞与年龄相关的变化背后的机制，以及它们是否可以靶向改善老年肌肉修复。