Research Fellowship

研究奖学金

• 批准号: nhmrc : 1019761
• 负责人: Prof Richard Lewis
• 金额: $ 49.34万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/research-fellowship/109980
• 关键词: Research; Fellowship

Professor Lewis is a molecular pharmacologist interested in discovering new venom peptides and ciguatoxins and determining how they interact with the membrane proteins they target using advanced biochemical and spectroscopic methods. Peptides of interest are then modified to improve potency and selectivity. Those with appropriate properties are patented and developed for clinical applications using approaches successfully applied to Xen2174, a conopeptide analogue I co-discovered that is now in Phase II clinical trials for severe pain.

刘易斯教授是一位分子药理学家，他对发现新的毒液肽和雪卡毒素感兴趣，并使用先进的生物化学和光谱方法确定它们如何与它们靶向的膜蛋白相互作用。然后对感兴趣的肽进行修饰以提高效力和选择性。那些具有适当特性的专利和开发用于临床应用，使用成功应用于Xen2174的方法，Xen2174是我共同发现的一种芋螺肽类似物，目前正处于严重疼痛的II期临床试验。