Restoring MHC class I antigen presentation to enhance anti-tumour immunity

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Immune checkpoint inhibitor (ICI) therapies boost the immune response against cancer cells and have been very effective in treating certain types of cancer. Unfortunately not all cancers respond to ICIs and a common cause of resistance is failure to express a molecule called MHC class I, which allows the tumour to hide from immune cells. This project will identify ways to restore MHC class I to the surface of resistant tumours to promote elimination by the immune system following ICI therapy.