Restoring MHC class I antigen presentation to enhance anti-tumour immunity

免疫检查点抑制剂（ICI）疗法可以增强对癌细胞的免疫反应，并且在治疗某些类型的癌症方面非常有效。不幸的是，并非所有的癌症都对ICI有反应，耐药的一个常见原因是未能表达一种称为MHC I类的分子，这使得肿瘤能够躲避免疫细胞。该项目将确定将MHC I类恢复到耐药肿瘤表面的方法，以促进ICI治疗后免疫系统的消除。

Immune checkpoint inhibitor (ICI) therapies boost the immune response against cancer cells and have been very effective in treating certain types of cancer. Unfortunately not all cancers respond to ICIs and a common cause of resistance is failure to express a molecule called MHC class I, which allows the tumour to hide from immune cells. This project will identify ways to restore MHC class I to the surface of resistant tumours to promote elimination by the immune system following ICI therapy.