Risk factors for chronic respiratory diseases in middle age: 36-year follow-up of the Tasmanian Asthma Study

中年慢性呼吸道疾病的危险因素：塔斯马尼亚哮喘研究的 36 年随访

• 批准号: nhmrc : 299901
• 负责人: A/Pr David Johns
• 金额: $ 23.92万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/risk-factors-chronic-asthma-study/98180
• 关键词: Risk; factors; chronic; respiratory; diseases

This project will improve our understanding of the causes of chronic respiratory diseases (CRDs) in adults. CRDs are clearly a major public health problem, but there are no good data on the natural history and risk factors for these diseases. Regular follow-up through childhood to adulthood is the best method to examine these factors, but such data is lacking due to difficulties in conducting long-term studies. The Tasmanian Asthma Study (TAS), based on 8,585 Tasmanians (i.e. probands) born in 1961, is one of the worlds most important resources of such information. The probands, their parents (16,267) and siblings (21,044) were first investigated for respiratory problems in 1968. Subsequently, three follow-up surveys were carried out at ages 13 (1974), 20 (1981) and 31 (1992) on either the total or sub-samples of the probands. In 1992, the children and spouses of the probands were also surveyed. Information on all respiratory problems was collected in all the follow-ups, although the main focus of the TAS to date has been asthma. The probands are now reaching the age at which all CRD as a group are beginning to inflict an increasing disease burden, which will become greater in the next two decades. Hence, TAS now provides an ideal opportunity to examine the potential risk factors and natural history of and of CRDs using data collected to date and new data collected at age 43. Also, it will provide a platform for future studies to investigate the progression of CRDs in this cohort. Hence, we propose to carry out the 36 year follow-up of this cohort focusing on CRDs. This will provide important information for preventing chronic respiratory morbidity and disability in the future, which will be original and significant not only in Australia but also internationally.

该项目将增进我们对成人慢性呼吸道疾病 (CRD) 病因的了解。 CRD 显然是一个主要的公共卫生问题，但没有关于这些疾病的自然史和危险因素的良好数据。从童年到成年的定期随访是检查这些因素的最佳方法，但由于难以进行长期研究，因此缺乏此类数据。塔斯马尼亚哮喘研究 (TAS) 以 1961 年出生的 8,585 名塔斯马尼亚人（即先证者）为基础，是世界上最重要的此类信息资源之一。先证者、他们的父母（16,267）和兄弟姐妹（21,044）于1968年首次接受了呼吸系统问题调查。随后，在13岁（1974年）、20岁（1981年）和31岁（1992年）时对先证者的全部样本或子样本进行了三项后续调查。 1992年，先证者的子女和配偶也接受了调查。尽管迄今为止 TAS 的主要关注点是哮喘，但在所有后续行动中都收集了所有呼吸系统问题的信息。先证者现在已经到了所有 CRD 作为一个群体开始造成日益增加的疾病负担的年龄，这种负担在未来二十年将变得更加严重。因此，TAS 现在提供了一个理想的机会，可以使用迄今为止收集的数据和 43 岁时收集的新数据来检查 CRD 的潜在风险因素和自然史。此外，它还将为未来的研究提供一个平台，以调查该队列中 CRD 的进展情况。因此，我们建议针对 CRD 对该队列进行 36 年的随访。这将为未来预防慢性呼吸道疾病和残疾提供重要信息，这不仅在澳大利亚而且在国际上都是原创且重要的。