The role of 14-3-3 proteins in regulating the innate immune response

14-3-3蛋白在调节先天免疫反应中的作用

• 批准号: nhmrc : 631915
• 负责人: Prof Douglas Brooks
• 金额: $ 34.54万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-14-3-immune-response/101044
• 关键词: role; 14; proteins; regulating; innate

The immune response is the body's defense system. It's malfunction leads to many diseases such as immune deficiency, asthma and cancer. Thus, it is important to find genes controlling immunity. Significantly, mammals have amazing similarities with flies, in terms of genes controlling immunity. We have found a new regulator of fly immunity and will define how this gene functions in the immune system. This project will identify potential points of intervention for treating immune system disorders.

免疫反应是人体的防御系统。它的故障会导致许多疾病，如免疫缺陷、哮喘和癌症。因此，找到控制免疫的基因是很重要的。值得注意的是，哺乳动物在控制免疫的基因方面与苍蝇有惊人的相似之处。我们已经发现了一种新的苍蝇免疫调节器，并将定义该基因在免疫系统中的功能。该项目将确定治疗免疫系统疾病的潜在干预点。