The role of A20 in beta cell survival

A20 在 β 细胞存活中的作用

• 批准号: nhmrc : 427648
• 负责人: Dr Shane Grey
• 金额: $ 33.54万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-a20-beta-cell-survival/95726
• 关键词: role; A20; beta; cell; survival

Diabetes mellitus is a disease reaching epidemic proprotions in the western world. Nearly one million Australians have diabetes mellitus; many of these people will suffer debilitating secondary complications, resulting in significant morbidity and mortality at considerable social and economic cost. Complications include heart attack, stroke, kidney disaease, blindness and limb amputation. There are two forms of diabetes (type I and type 2), and though there are considerable differences in their etiology, both forms result in an inability of the body to control blood sugar levels. Beta cells release the hormone insulin, which regulates blood sugar levels. Current knowledge suggests that a loss of beta cell mass is important for both diseases. For type I diabetes the beta cells are destroyed by the immune system. Though for type 2 diabetes the causes are less clear, it is apparent that the beta cells are dying. Our research is focused on understanding the molecular pathways that control beta cell survival and regulate their death. Such knowledge would help us understand the complex processes leading to the development of diabetes. Furthermore, we could use this knowledge in the design of genetic engineering strategies to create 'death-defying' beta cells, as a potential therapeutic strategy for the treatment of diabetes.

糖尿病是一种在西方世界达到流行趋势的疾病。近百万澳大利亚人患有糖尿病；其中许多人将遭受继发性并发症，导致严重的发病率和死亡率，造成相当大的社会和经济成本。并发症包括心脏病、中风、肾病、失明和截肢。糖尿病有两种形式（I 型和 2 型），尽管其病因存在很大差异，但这两种形式都会导致身体无法控制血糖水平。 β细胞释放激素胰岛素，调节血糖水平。目前的知识表明，β细胞质量的损失对于这两种疾病都很重要。对于 I 型糖尿病，β 细胞会被免疫系统破坏。尽管 2 型糖尿病的原因尚不清楚，但很明显，β 细胞正在死亡。我们的研究重点是了解控制 β 细胞存活和调节其死亡的分子途径。这些知识将帮助我们了解导致糖尿病发展的复杂过程。此外，我们可以利用这些知识设计基因工程策略来创造“挑战死亡”的β细胞，作为治疗糖尿病的潜在治疗策略。