Role of adiponectin in hepatic carcinogenesis

脂联素在肝癌发生中的作用

• 批准号: nhmrc : 1006200
• 负责人: Dr Lionel Hebbard
• 金额: $ 24.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-adiponectin-hepatic-carcinogenesis/109154
• 关键词: Role; adiponectin; hepatic; carcinogenesis

Overweight individuals have an increased risk for developing liver cancer. This may be due to the reduced production of the fat-derived hormone adiponectin. Reduced levels of adiponectin are associated with increased inflammation and liver disease. Using mice not expressing adiponectin we will test its importance in liver cancer growth. The proposed research will provide a better understanding of the factors that promote liver cancer formation.

超重的人患肝癌的风险增加。这可能是由于脂肪衍生荷尔蒙脂联素的产生减少所致。脂联素水平的降低与炎症和肝脏疾病的增加有关。利用不表达脂联素的小鼠，我们将测试它在肝癌生长中的重要性。这项拟议的研究将使人们更好地了解促进肝癌形成的因素。