The role of airway neutrophilia in the structural and functional characteristics of severe asthma and its effect on steroid-resistance

气道中性粒细胞增多在严重哮喘结构和功能特征中的作用及其对类固醇抵抗的影响

• 批准号: nhmrc : 1053790
• 负责人: Dr David Chapman
• 金额: $ 21.65万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-airway-neutrophilia-steroid-resistance/112349
• 关键词: role; airway; neutrophilia; structural; functional

While many cases of asthma are mild, severe cases require extensive health care resources and are virtually unresponsive to conventional treatment. This project will investigate whether specific compounds released from the airway are able to cause lung damage and airway abnormalities similar to that in severe asthma. We will investigate whether these changes are responsive to conventional therapy and investigate a potential treatment for regaining this responsiveness in severe asthma.

虽然许多哮喘病例是轻度的，但严重的病例需要大量的卫生保健资源，并且对常规治疗几乎没有反应。该项目将调查从气道释放的特定化合物是否能够导致类似于严重哮喘的肺损伤和气道异常。我们将研究这些变化是否对常规治疗有反应，并研究在严重哮喘中恢复这种反应性的潜在治疗方法。