The role of centromere defects in cancer formation and progression

着丝粒缺陷在癌症形成和进展中的作用

• 批准号: nhmrc : 1031089
• 负责人: Dr Paul Kalitsis
• 金额: $ 40.1万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-centromere-defects-formation-progression/110787
• 关键词: role; centromere; defects; cancer; formation

When cells divide, their DNA must be copied and distributed faultlessly into the new cells. Defects in the factors that control this process will result in serious health problems including cancer. The objective of this project is to identify what these factors are and study how they contribute to cancer. Results gained from this project are expected to significantly increase our understanding of how cancer cells control the replication of their DNA and therefore their own fate.

当细胞分裂时，它们的DNA必须被复制并错误地分配到新细胞中。控制这一过程的因素的缺陷将导致严重的健康问题，包括癌症。该项目的目的是确定这些因素是什么，并研究它们如何导致癌症。从这个项目中获得的结果预计将显着增加我们对癌细胞如何控制其DNA复制的理解，从而控制其自身的命运。