The role of the chemosensory receptors of the enteric pathogen C. jejuni in virulence and host - bacterial interactions

肠道病原体空肠弯曲菌化学感应受体在毒力和宿主-细菌相互作用中的作用

• 批准号: nhmrc : 1004490
• 负责人: Prof Victoria Korolik
• 金额: $ 34.53万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-chemosensory-receptors-bacterial-interactions/109039
• 关键词: role; chemosensory; receptors; enteric; pathogen

Campylobacter jejuni is the greatest cause of bacterial gastroenteritis in the world. Consumption of contaminated meat or untreated water leads to disease often requiring hospitalisation. Campylobacter infection is also linked to the development of neoroparalytic disorders and reactive arthritis. This project aims to determine how this pathogen utilises surface molecules to sense its environment and cause disease. This information may be exploited to develop new treatments for mucosal infections.

空肠弯曲菌是世界上最大的细菌性胃肠炎的原因。食用受污染的肉类或未经处理的水会导致疾病，通常需要住院治疗。弯曲杆菌感染也与新溶血性疾病和反应性关节炎的发展有关。该项目旨在确定这种病原体如何利用表面分子来感知其环境并引起疾病。这些信息可能被用来开发新的治疗粘膜感染的方法。