Role of connective tissue growth factor in the pathobiology of lymphoid tumours and response to therapy

结缔组织生长因子在淋巴肿瘤病理学和治疗反应中的作用

• 批准号: nhmrc : 1007586
• 负责人: Dr Adrian Charles
• 金额: $ 40.25万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-connective-tissue-response-therapy/109229
• 关键词: Role; connective; tissue; growth; factor

Leukaemia is the most common cancer in children and the improved cure rates are among the major biomedical advances of the past five decades. However, we still do not fully understand why leukaemia cells have a growth advantage. We identified the growth factor CTGF as being massively activated in leukaemia cells. The project aims to study the role of CTGF in bringing about the disease. Insights gained are expected to lead towards novel treatments for patients with leukaemia.

白血病是儿童中最常见的癌症，治愈率的提高是过去五十年来生物医学的主要进步之一。然而，我们仍然不完全理解为什么白血病细胞具有生长优势。我们发现生长因子CTGF在白血病细胞中被大量激活。该项目旨在研究CTGF在导致疾病中的作用。所获得的见解有望为白血病患者带来新的治疗方法。