Examining novel cell signalling in the regulation of platelet structure and function

检查血小板结构和功能调节中的新细胞信号传导

• 批准号: FT130100540
• 负责人: A/Prof Justin Hamilton
• 金额: $ 52.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100540
• 关键词: Examining; novel; cell; signalling; regulation

Pharmaceutical inhibition of platelet function is the primary therapy for prevention of arterial thrombosis – the most common cause of death and disability in Australia. However, current therapies have limited efficacy. Defining platelet activation mechanisms in order to rationalise more effective antithrombotic approaches is the major focus of this research. This project describes the first studies to examine the importance of a family of intracellular signalling enzymes, the Class II phosphoinositide 3-kinases, in platelet function. These studies will define the contribution of these enzymes to platelet production and function and will establish whether their inhibition is an attractive strategy for the prevention of arterial thrombosis.

药物抑制血小板功能是预防动脉血栓形成的主要治疗方法，动脉血栓是澳大利亚最常见的死亡和残疾原因。然而，目前的治疗方法疗效有限。为了使更有效的抗血栓治疗方法合理化，明确血小板激活机制是本研究的主要重点。这个项目描述了第一次研究细胞内信号转导酶家族，第二类磷脂酰肌醇3-激动酶，在血小板功能中的重要性。这些研究将确定这些酶对血小板产生和功能的贡献，并将确定抑制它们是否是预防动脉血栓形成的有吸引力的策略。