Role for Dipeptidyl Peptidase-IV in the Innate Immune Response

二肽基肽酶-IV 在先天免疫反应中的作用

• 批准号: nhmrc : 1016662
• 负责人: Dr Roger Yazbek
• 金额: $ 20.15万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dipeptidyl-peptidase-immune-response/109798
• 关键词: Role; Dipeptidyl; Peptidase; IV; Innate

The innate immune system is the bodyÍs first line of defence in fighting off infections by invading organisms. An inappropriate innate immune response can lead to the development of several inflammatory conditions such as inflammatory bowel disease. A malfunctioning innate immune response has been identified in children with IBD. This project will determine the role of a unique enzyme called DPIV in the development of innate immune responses and its potential as a therapeutic target for IBD.

先天免疫系统是人体抵御入侵生物体感染的第一道防线。不适当的先天免疫反应可导致几种炎症性疾病的发展，如炎症性肠病。先天性免疫应答功能障碍已在IBD儿童中发现。该项目将确定一种名为DPIV的独特酶在先天免疫反应发展中的作用及其作为IBD治疗靶点的潜力。