The role of ezrin-radixin-moesin proteins, novel binding proteins for advanced glycation endproducts, in kidney cells

糖尿病中的高葡萄糖水平与蛋白质反应形成AGEs，并且认为这种反应可能导致肾脏损伤，这是糖尿病的并发症之一。然而，这种损害是如何发生的还不完全清楚。细胞需要保持它们的形状和位置，以使器官保持健康。我们已经表明，AGEs通过与维持细胞形状的蛋白质相互作用并干扰其功能来影响肾细胞。我们现在要研究这是如何发生的。

High glucose levels in diabetes react with proteins to form AGEs and it is thought that this reaction may lead to kidney damage, which is one of the complications of diabetes. However, how this damage occurs is not completely understood. Cells need to maintain their shape and position for an organ to stay healthy. We have shown that AGEs affect kidney cells by interacting with and disturbing the function of proteins that maintain cell shape. We now want to study how this occurs.