The role of inflammation in viral pathogenesis and exacerbations of asthma

炎症在病毒发病机制和哮喘恶化中的作用

• 批准号: nhmrc : 1054081
• 负责人: Dr Kirsty Short
• 金额: $ 26.32万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-inflammation-viral-exacerbations-asthma/112366
• 关键词: role; inflammation; viral; pathogenesis; exacerbations

A strong immune response is essential for protection against viral infections. However, in some circumstances a strong immune response against viruses can actually further aggravate disease. In addition, an anti-viral immune response can trigger asthma attacks in allergic individuals. This research thus seeks to understand and therefore mitigate the potentially detrimental role of inflammation in influenza virus infections and asthma.

强大的免疫反应对于防止病毒感染至关重要。然而，在某些情况下，对病毒的强烈免疫反应实际上会进一步加重疾病。此外，抗病毒免疫反应可引发过敏个体的哮喘发作。因此，这项研究旨在了解并减轻炎症在流感病毒感染和哮喘中的潜在有害作用。