Role of neuroinflammation and neurotransmitter systems in the improved cognition induced by estrogen receptor modulation

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Cognitive problems prevent people with schizophrenia from studying, working and forming social connections. There are no clinical treatments for cognitive problems. We have found that the estrogen receptor modulator, raloxifene, improves cognition in people with schizophrenia. Determining the molecular mechanisms that contribute to this improvement in cognition will provide molecular targets for the development of more effective therapeutics to enhance cognition and prevent cognitive decline.