Role of neuroinflammation and neurotransmitter systems in the improved cognition induced by estrogen receptor modulation

神经炎症和神经递质系统在雌激素受体调节引起的认知改善中的作用

• 批准号: nhmrc : GNT1160399
• 金额: $ 71.25万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-neuroinflammation-neurotransmitter-receptor-modulation/1379126
• 关键词: Role; neuroinflammation; neurotransmitter; systems; improved

Cognitive problems prevent people with schizophrenia from studying, working and forming social connections. There are no clinical treatments for cognitive problems. We have found that the estrogen receptor modulator, raloxifene, improves cognition in people with schizophrenia. Determining the molecular mechanisms that contribute to this improvement in cognition will provide molecular targets for the development of more effective therapeutics to enhance cognition and prevent cognitive decline.

认知问题阻碍精神分裂症患者学习、工作和建立社会联系。认知问题没有临床治疗方法。我们发现雌激素受体调节剂雷洛昔芬可以改善精神分裂症患者的认知能力。确定有助于这种认知改善的分子机制将为开发更有效的治疗方法提供分子靶点，以增强认知和预防认知下降。