The role of a new class of chromatin organising hub

新型染色质组织中心的作用

• 批准号: nhmrc : GNT1128748
• 负责人: Prof John Rasko
• 金额: $ 114.55万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-new-class-organising-hub/1347709
• 关键词: role; new; class; chromatin; organising

Within the cell nucleus, specific proteins weave DNA into structured loops that are vital for normal cell function. By studying the molecules involved, we have uncovered a ‘dock’ that controls this DNA architecture. We will define the components and function of this ‘dock’, and the resulting rapid cell death that occurs if it is disrupted. We will explore this cell death pathway thoroughly because we think it may help us to develop new cancer therapies.

在细胞核内，特定的蛋白质将DNA编织成对正常细胞功能至关重要的结构环。通过研究相关分子，我们发现了一个控制这种DNA结构的“码头”。我们将定义这个“码头”的组成和功能，以及如果它被破坏所导致的细胞快速死亡。我们将彻底探索这种细胞死亡途径，因为我们认为它可能有助于我们开发新的癌症治疗方法。