The role of NF-?B transcription factor RelA in regulatory T cell homeostasis and function

NF-κB转录因子RelA在调节T细胞稳态和功能中的作用

• 批准号: nhmrc : 1069075
• 负责人: Dr Ashish Banerjee
• 金额: $ 42.48万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-nf-b-homeostasis-function/455369
• 关键词: role; NF; transcription; factor; RelA

Treg cells constitute an immune regulatory cell population that is essential for the prevention of fatal autoimmunity; however, they also limit immunity against cancer. We have discovered that the factor RelA is of critical importance for Treg development and function. We now aim to illuminate the functions of RelA in detail. Understanding the molecules that impact on Treg cell biology is critical to harness their potential for clinical intervention such as treatment of autoimmunity and cancer.

Treg细胞构成了一种免疫调节细胞群，对于预防致命的自身免疫是必不可少的；然而，它们也限制了对癌症的免疫。我们发现Rela因子对Treg的发育和功能至关重要。我们现在的目标是详细说明RELA的功能。了解影响Treg细胞生物学的分子对于利用它们的临床干预潜力至关重要，例如治疗自身免疫和癌症。