Role of the novel TGF-b superfamily cytokine MIC-1 in the pathogenesis and treatment of rheumatoid arthritis

新型TGF-b超家族细胞因子MIC-1在类风湿关节炎发病机制和治疗中的作用

• 批准号: nhmrc : 157031
• 负责人: Prof Malcolm Smith
• 金额: $ 20.64万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-novel-tgf-rheumatoid-arthritis/100801
• 关键词: Role; novel; TGF; superfamily; cytokine

Cytokines are hormone like messengers that mediate the interactions between cells. We have discovered a new cytokine that we have named macrophage inhibitory cytokine 1 (MIC-1). It belongs to a very important family of proteins that are involved in wound healing, development and inflammation. Our data thus far suggests that MIC-1 is an anti-inflammatory factor that is of particular relevance in rheumatoid arthritis. We wish to determine the relationship between the amount of this cytokine in the joint and the blood and the activity of rheumatoid arthritis. To better understand the actions of this molecule, we also want to study the factors that regulate the production of MIC-1 from human blood cells. Finally, to assess whether MIC-1 is useful for the treatment of rheumatoid arthritis, we will use gene therapy approaches to develop animals that produce increased amounts of MIC-1 and determine whether this prevents or mitigates the development of rheumatoid arthritis.

细胞因子是激素一样的信使，介导细胞之间的相互作用。我们发现了一种新的细胞因子，我们命名为巨噬细胞抑制细胞因子1 （MIC-1）。它属于一个非常重要的蛋白质家族，与伤口愈合、发育和炎症有关。到目前为止，我们的数据表明MIC-1是一种与类风湿性关节炎特别相关的抗炎因子。我们希望确定关节和血液中这种细胞因子的数量与类风湿关节炎活动之间的关系。为了更好地理解这种分子的作用，我们还想研究调节人类血细胞中MIC-1产生的因素。最后，为了评估MIC-1是否对类风湿关节炎的治疗有用，我们将使用基因治疗方法来培养产生更多MIC-1的动物，并确定这是否可以预防或减轻类风湿关节炎的发展。