The role of NOX4 in muscle antioxidant defence and mitochondrial biogenesis

NOX4 在肌肉抗氧化防御和线粒体生物发生中的作用

• 批准号: nhmrc : GNT1162798
• 金额: $ 82.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-nox4-muscle-mitochondrial-biogenesis/1379253
• 关键词: role; NOX4; muscle; antioxidant; defence

This proposal aims to shed light on the molecular mechanisms underpinning the health-promoting effects of exercise. This proposal will focus on defining how reactive oxygen species contribute to exercise-induced adaptive responses in muscle that promote metabolic health and prevent the age-related decline in muscle function. Our studies will shed light on mechanisms that help prevent disease in our increasingly sedentary and ageing populations.

该提案旨在阐明运动促进健康作用的分子机制。该提案将重点定义活性氧如何促进运动引起的肌肉适应性反应，从而促进代谢健康并防止与年龄相关的肌肉功能下降。我们的研究将揭示有助于预防久坐和老龄化人口疾病的机制。