The role of p75 neurotrophin receptor-mediated neurodegeneration of basal forebrain cholinergic neurons

p75神经营养素受体介导的基底前脑胆碱能神经元神经变性的作用

• 批准号: nhmrc : 569886
• 负责人: Dr Adam Hamlin
• 金额: $ 21.39万
• 依托单位: Charles Sturt University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-p75-neurotrophin-cholinergic-neurons/116138
• 关键词: role; p75; neurotrophin; receptor; mediated

Alzheimer’s disease is a progressive neurodegenerative disorder characterized by clinical symptoms of memory deficits and cognitive function. It remains unclear what causes Alzheimer’s disease, but loss of a specific population of brain cells that are critical to cognitive function is generally accepted as a key feature of this condition. The aim of this project is to understand the mechanisms by which this cell loss occurs and how this relates to the loss of brain function.

阿尔茨海默病是一种进行性神经退行性疾病，其特征在于记忆缺陷和认知功能的临床症状。目前尚不清楚是什么原因导致阿尔茨海默病，但对认知功能至关重要的特定脑细胞群的丧失被普遍认为是这种疾病的一个关键特征。该项目的目的是了解这种细胞损失发生的机制以及这与大脑功能丧失的关系。