Membrane interactions and diacylglycerol kinases

膜相互作用和二酰甘油激酶

• 批准号: 9848-2008
• 负责人: Epand, Richard
• 金额: $ 4.26万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=390021
• 关键词: Membrane; interactions; diacylglycerol; kinases

Mammalian diacylglycerol kinases (DGKs) have an important role in regulating functions that are specific to higher organisms such as brain activity, immunological response and cell proliferation. Our studies on the properties of several forms of DGK will lead to a better understanding of their function and provide the ability to modulate their properties. This will have relevance for pathological states such as cancer.

哺乳动物二酰甘油激酶 (DGK) 在调节高等生物特有的功能（如大脑活动、免疫反应和细胞增殖）方面发挥着重要作用。我们对几种形式的 DGK 特性的研究将有助于更好地理解它们的功能并提供调节其特性的能力。这与癌症等病理状态有关。