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the energetics of conformational interconversions plasminogen

the energetics of conformational interconversions plasminogen
纤溶酶原构象相互转化的能量学
批准号:
9988-2006
负责人:
Kornblatt, Jack
金额:
$3.22万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2008
资助国家:
加拿大
项目状态:
已结题
起止时间:
2008-01-01 至 2009-12-31

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中文摘要
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英文摘要
We study the blood protein, plasminogen.  It is the body's first line of defense against unwanted, internal blood clots.  It is also involved in tissue remodeling such as occurs during lactation and tumour metastasis.  Plasminogen binds to a clot or cell, opens and can then be activated to plasmin, the enzymatic form.  On binding, the plasminogen undergoes a large conformational change; it is part of the activation process.  Our long term goal is to be able to activate plasminogen at will when it is desirable, and inhibit its activation when it is undesirable.  In order to do that we need a firm grasp of the factors that dictate which conformations are present, when they are present and what promotes or inhibits their interconversion.
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the energetics of conformational interconversions plasminogen
  • 批准号:
    9988-2006
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.22万
  • 财政年份:
    2015
  • 负责人:
    Kornblatt, Jack
  • 依托单位:
the energetics of conformational interconversions plasminogen
  • 批准号:
    9988-2006
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.22万
  • 财政年份:
    2012
  • 负责人:
    Kornblatt, Jack
  • 依托单位:
the energetics of conformational interconversions plasminogen
  • 批准号:
    9988-2006
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.22万
  • 财政年份:
    2011
  • 负责人:
    Kornblatt, Jack
  • 依托单位:
the energetics of conformational interconversions plasminogen
  • 批准号:
    9988-2006
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.22万
  • 财政年份:
    2010
  • 负责人:
    Kornblatt, Jack
  • 依托单位:
国内基金
海外基金
聚谷氨酰胺(PolyQ)疾病致病蛋白构象多态性的研究及应用
  • 批准号:
    31970748
  • 项目类别:
    面上项目
  • 资助金额:
    60.0万元
  • 批准年份:
    2019
  • 负责人:
    付玉华
  • 依托单位: