Role of PTEN catalytic function in suppression of cancer and metastasis

PTEN 催化功能在抑制癌症和转移中的作用

• 批准号: nhmrc : GNT1100307
• 负责人: Dr Antonella Papa
• 金额: $ 75.83万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-pten-catalytic-cancer-metastasis/1346112
• 关键词: Role; PTEN; catalytic; function; suppression

PTEN mutations are frequently described in various types of cancer. This proposal outlines different experimental strategies to probe how modulation of distinct PTEN functions can affect signalling pathways and be responsible for oncogenic outcomes. We will use animal models and cell lines in culture to identify new signatures/biomarkers to stratifying patients on genetic and molecular bases, and to facilitate the design of tailored combinational therapies directed toward cancer eradication.

PTEN突变经常出现在各种类型的癌症中。该提案概述了不同的实验策略，以探索不同PTEN功能的调节如何影响信号通路并负责致癌结果。我们将使用动物模型和培养细胞系来识别新的特征/生物标记物，从而根据遗传和分子基础对患者进行分层，并促进针对癌症根除的量身定制的组合疗法的设计。