The Role of Raptor and Rictor Signalling Pathways in Osteogenesis and Mesenchymal Stem Cell Fate Determination

Raptor 和 Rictor 信号通路在成骨和间充质干细胞命运决定中的作用

• 批准号: nhmrc : 1030528
• 负责人: Dr Stephen Fitter
• 金额: $ 37.52万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-raptor-rictor-fate-determination/110761
• 关键词: Role; Raptor; Rictor; Signalling; Pathways

Skeletal diseases associated with excessive bone loss and skeletal fragility, such as osteoporosis, affect 2.2 million Australians and cost our health system approximately $7.4 billion per annum. Studies from our laboratory suggest a critical role for the mTOR signalling pathway in bone development. Using transgenic animals and state-of-the-art techniques, we will investigate the role of mTOR in pre- and post-natal skeletal development. Results from these studies may provide novel approaches to treat age-related bone loss syndromes.

与骨质过度流失和骨骼脆弱有关的骨骼疾病，如骨质疏松症，影响着220万澳大利亚人，每年使我们的卫生系统损失约74亿澳元。我们实验室的研究表明mTOR信号通路在骨发育中起关键作用。利用转基因动物和最先进的技术，我们将研究mTOR在出生前和出生后骨骼发育中的作用。这些研究的结果可能为治疗年龄相关性骨丢失综合征提供新的方法。