Bioorganic chemistry

生物有机化学

• 批准号: 104262-2008
• 负责人: White, Robert
• 金额: $ 1.82万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=390827
• 关键词: Bioorganic; chemistry

The discovery of new pharmaceuticals is an important intellectual and commercial endeavour. In this application, funding is requested to advance the science behind fundamental biological and chemical processes. Objectives of the proposed research include the identification of new bacterial protein targets for antibiotic action, the chemical synthesis of enzyme inhibitors as potential antibiotics, and the characterization of the fundamental reactivity of negative ions in the gas phase. The latter will answer important questions in our understanding of processes used for the analysis of ions by mass spectrometry, the major tool used in drug metabolism studies during drug development. Our studies focus on amino acids, an important group of biomolecules that not only are incorporated into proteins, but also serve as integral components of the bacterial cell wall and act as neurotransmitters in mammals. In addition, amino acids are major sources of carbon, nitrogen and energy for anaerobic bacteria associated with periodontal disease, a disease that leads to degradation of gum tissue and increases the risk of coronary heart disease. The metabolism of amino acids in anaerobic bacteria differs from that in humans; our studies will further define these differences with the goal of developing effective and selective metabolic inhibitors that are potential antibiotics. Overall our research program in Bioorganic Chemistry will provide important insights into bacterial metabolism and mass spectrometry of biologically relevant molecules, yielding new mechanisms for the interpretation and application of fundamental processes.

新药的发现是一项重要的智力和商业努力。在这项申请中，要求提供资金，以推进基本生物和化学过程背后的科学。拟议研究的目标包括确定新的细菌蛋白质抗生素作用的目标，酶抑制剂作为潜在抗生素的化学合成，以及表征气相中负离子的基本反应性。后者将回答我们对质谱法离子分析过程的理解中的重要问题，质谱法是药物开发过程中药物代谢研究的主要工具。我们的研究重点是氨基酸，这是一组重要的生物分子，不仅被纳入蛋白质，而且还作为细菌细胞壁的组成部分，并作为哺乳动物的神经递质。此外，氨基酸是与牙周病相关的厌氧菌的碳、氮和能量的主要来源，牙周病是一种导致牙龈组织降解并增加冠心病风险的疾病。厌氧菌中氨基酸的代谢与人类不同;我们的研究将进一步确定这些差异，目的是开发有效和选择性的代谢抑制剂，这些抑制剂是潜在的抗生素。总的来说，我们在生物有机化学的研究计划将提供重要的见解细菌代谢和生物相关分子的质谱分析，产生新的机制的基本过程的解释和应用。