The role of the systemic milieu in preventing motor unit remodelling and loss during ageing

全身环境在预防衰老过程中运动单位重塑和损失中的作用

• 批准号: nhmrc : 1054595
• 负责人: Dr Stefan Gehrig
• 金额: --
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-systemic-milieu-loss-ageing/112406
• 关键词: role; systemic; milieu; preventing; motor

Motor unit remodeling and loss contributes to the decline in muscle mass, strength and quality of life in our aging population. Recent data shows that exposing aged mice to 'blood-borne factors' from the circulation of a young mouse can reverse the age-associated deficits in motor unit structure and function. A better understanding of the factors controlling these anti-aging effects will be vital for finding new compounds to reverse the aging process and improve quality of life.

运动单位的重塑和损失导致我们老龄化人口中肌肉质量、力量和生活质量的下降。最近的数据表明，将老年小鼠暴露于年轻小鼠循环中的“血液传播因子”可以逆转与年龄相关的运动单位结构和功能缺陷。更好地了解控制这些抗衰老作用的因素对于寻找新的化合物来逆转衰老过程和提高生活质量至关重要。