Role of Tenascin-C and TLR-4 in carotid atherosclerosis related stroke

Tenascin-C 和 TLR-4 在颈动脉粥样硬化相关卒中中的作用

• 批准号: nhmrc : 1011649
• 负责人: A/Pr Lisa Lincz
• 金额: $ 20.54万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-tenascin-c-related-stroke/109606
• 关键词: Role; Tenascin; TLR; carotid; atherosclerosis

It is estimated that approximately 10,000 Australians per year suffer from strokes related to neck artery disease. Warning signs often go undiagnosed and unreported. Currently there are no blood tests available for early simple diagnosis and few specific drugs available to reduce the number of strokes. Based on preliminary studies we will investigate the role of a novel protein and its related pathway in stroke. We will also study the value of these proteins as a blood test for this problem.

据估计，每年约有10,000名澳大利亚人患有与颈部动脉疾病有关的中风。警告信号往往未被诊断和报告。目前，没有血液检查可以用于早期简单诊断，也没有专门的药物可以减少中风的数量。在初步研究的基础上，我们将研究一种新的蛋白及其相关途径在脑卒中中的作用。我们还将研究这些蛋白质作为血液测试的价值。