The role of TRAIL and TRAIL receptors in atherosclerosis

TRAIL和TRAIL受体在动脉粥样硬化中的作用

• 批准号: nhmrc : 568627
• 负责人: Dr Mary Kavurma
• 金额: $ 37.6万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-trail-trail-receptors-atherosclerosis/78284
• 关键词: role; TRAIL; receptors; atherosclerosis

The death factor, TNF-related apoptosis inducing ligand (TRAIL) is implicated in the development of atherosclerosis and can regulate cell death in the vessel wall. Recent conflicting roles for TRAIL have been described. Surprisingly, TRAIL can also stimulate cell growth. Using mice lacking TRAIL, this study will establish the function of TRAIL in models of (i) injury to the artery wall and (ii) an atherosclerotic plaque. This study will also initiate a new area of research in Australia.

死亡因子肿瘤坏死因子相关的凋亡诱导配体(TRAIL)参与动脉粥样硬化的发生发展，调节血管壁上的细胞死亡。最近对TRAIL的角色冲突进行了描述。令人惊讶的是，TRAIL还能刺激细胞生长。利用缺乏TRAIL的小鼠，本研究将确定TRAIL在(I)动脉壁损伤和(Ii)动脉粥样硬化斑块模型中的作用。这项研究还将在澳大利亚开创一个新的研究领域。