The role of the transcription factor Blimp-1 in tumour immunity

调节性T（Treg）细胞通过抑制免疫系统活性发挥作用，确保我们的免疫系统不会对我们自己的组织产生反应。在癌症中，Treg细胞抑制抗肿瘤免疫，促进肿瘤生长。最近，我们已经确定了一组活性Treg细胞，它们可能是免疫应答调节的关键驱动因素。我们的工作将研究这些活性Treg细胞在肿瘤免疫中的作用，为更有效地靶向癌症中的Treg细胞打开大门。

Regulatory T (Treg) cells function by suppressing immune system activity, ensuring that our immune system does not mount a response against our own tissue. In cancer, Treg cells suppress anti-tumour immunity, facilitating tumour growth. Recently we have identified a group of active Treg cells that may be the key drivers of immune response regulation. Our work will examine the role of these active Treg cells in tumour immunity, opening the door to more effective targeting of Treg cells in cancer.