The role of the transcription factor Blimp-1 in tumour immunity

转录因子Blimp-1在肿瘤免疫中的作用

• 批准号: nhmrc : 1047313
• 负责人: Dr Erika Cretney
• 金额: $ 42.85万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-transcription-factor-tumour-immunity/111929
• 关键词: role; transcription; factor; Blimp; tumour

Regulatory T (Treg) cells function by suppressing immune system activity, ensuring that our immune system does not mount a response against our own tissue. In cancer, Treg cells suppress anti-tumour immunity, facilitating tumour growth. Recently we have identified a group of active Treg cells that may be the key drivers of immune response regulation. Our work will examine the role of these active Treg cells in tumour immunity, opening the door to more effective targeting of Treg cells in cancer.

调节性 T (Treg) 细胞通过抑制免疫系统活动发挥作用，确保我们的免疫系统不会对我们自身的组织做出反应。在癌症中，Treg 细胞抑制抗肿瘤免疫，促进肿瘤生长。最近我们发现了一组活跃的 Treg 细胞，它们可能是免疫反应调节的关键驱动因素。我们的工作将研究这些活跃的 Treg 细胞在肿瘤免疫中的作用，为更有效地靶向癌症中的 Treg 细胞打开大门。