Roles of Cascades of Transforming Growth Factor-beta and Matrix Metalloproteinases in the Impact of Cancer Stem Cells on the Neoplasm Formation of Oral Squamous Cell Carcinoma.

口腔癌患者的治疗失败是因为特定的癌细胞逃避化学-放射治疗。这些细胞具有自我更新和快速生长的特点，被称为癌症干细胞（CSC）。我们将测试我们的假设“的基因TGF-？1和MMP启动CSC“使用我们的细胞-小鼠模型来阻止癌症进展，并验证CSC对癌症形成的影响。这项研究对于了解如何阻止CSC并提供开发靶向抗癌治疗的机会至关重要。

Failure of treatment of oral cancer patients is because the specific cancer cells escape from chemo-radiotherapy. These cells feature self-renew and fast growth, which are called cancer stem cells (CSC). We will test our hypothesis “the genes of TGF-?1 and MMP initiate CSCs” using our cell-mouse models to arrest cancer progression, and verify the impact of CSC on cancer formation. This study is critical to know how to arrest CSC and offer an opportunity to develop a targeted anti-cancer therapy.